Protein could be target for new dementia therapies

Create: 09/20/2017 - 17:32

A protein that helps break down lipids in the cell’s lysosome may be a key target for identifying and treating neurodegenerative diseases, according to a study by the Peter O’Donnell Jr. Brain Institute at UT Southwestern Medical Center.

For decades, scientists have focused heavily on developing therapies targeting amyloid proteins that accumulate in degenerative brains, but disappointing results have spurred efforts to find alternative approaches.

The latest research highlights the therapeutic potential of a lysosomal protein called progranulin, which the study found appears to play a pivotal role in how the cell breaks down lipids.

“A lack of progranulin in the cell’s lysosome causes dysfunction in the organelle, a situation that is characteristic of many neurodegenerative diseases. By finding ways to boost progranulin production, scientists may be able to prevent or treat different types of dementia such as frontotemporal lobar degeneration (FTLD),” said Dr. Joachim Herz, who led the study and is Director of UT Southwestern’s Center for Translational Neurodegeneration Research.

In the study published in Cell Reports, the Herz Lab examined brain tissue of humans and mice to demonstrate how lipids in the lysosome are regulated by progranulin. This and other proteins are deficient in the lysosome in nearly half of all inherited FTLD cases because of mutations in the progranulin gene.

However, these FTLD patients typically have only one mutated copy of the gene. The remaining normal copy of the gene can potentially be targeted by novel therapies to boost progranulin expression and production, said Dr. Bret Evers, the study’s co-first author.

“Determining the role of progranulin within the cell is of vital importance if new therapies are to be created,” said Dr. Evers, Assistant Instructor in the Department of Pathology.

In addition, the study documented how brain tissue that lacked progranulin showed a unique lipid pattern that was different from other neurodegenerative diseases such as Alzheimer’s disease, which had its own distinct lipid pattern.

These “lipid fingerprints” allow scientists to distinguish between conditions that otherwise have several overlapping symptoms, Dr. Evers said. In the future, lipid patterns may help clinicians diagnose disease in its early stages.

“Determining the type of neurodegenerative disorder early in its course before overt symptoms appear will provide patients with more treatment options that better target the underlying disorder to slow its progression,” Dr. Evers said.

Science news reference:

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency. Bret M. Evers, Carlos Rodriguez-Navas, Rachel J. Tesla, Joachim Herz etal. Cell Reports, 2017. DOI:10.1016/j.celrep.2017.08.056

Science news source:

UT Southwestern

Tags: lysosome,Progranulin,dementia,frontal lobe degeneration,degenerative brain diseases

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